| Item Type | Name |
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Academic Article
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HIV-1 infection induces a selective reduction in STAT5 protein expression.
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Academic Article
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Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation.
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Academic Article
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Unique advantage of Janus kinase 3 as a target for selective and nontoxic immunosuppression.
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Academic Article
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JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.
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Academic Article
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Selective disruption of interleukin 4 autocrine-regulated loop by a tyrosine kinase inhibitor restricts activity of T-helper 2 cells.
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Academic Article
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Analysis of Janus tyrosine kinase phosphorylation and activation.
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Academic Article
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Interleukin-2 Receptor ? Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules.
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Academic Article
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Sensitivity of imatinib-resistant T315I BCR-ABL CML to a synergistic combination of ponatinib and forskolin treatment.
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Academic Article
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Impact of CTLA-4 blockade in conjunction with metronomic chemotherapy on preclinical breast cancer growth.
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Academic Article
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Structural domains of interleukin-2 receptor beta critical for signal transduction: kinase association and nuclear complex-formation.
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Academic Article
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The prohibitin protein complex promotes mitochondrial stabilization and cell survival in hematologic malignancies.
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Academic Article
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Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless.
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Academic Article
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Isoproterenol-induced beta-2 adrenergic receptor activation negatively regulates interleukin-2 signaling.
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Academic Article
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Optimization of biomarkers-based classification scores as progression-free survival predictors: an intuitive graphical representation.
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Academic Article
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The Research Centers in Minority Institutions (RCMI) Translational Research Network: Building and Sustaining Capacity for Multi-Site Basic Biomedical, Clinical and Behavioral Research.
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Academic Article
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Bif-1 Interacts with Prohibitin-2 to Regulate Mitochondrial Inner Membrane during Cell Stress and Apoptosis.
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Academic Article
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Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha.
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Academic Article
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Green barley mitigates cytotoxicity in human lymphocytes undergoing aggressive oxidative stress, via activation of both the Lyn/PI3K/Akt and MAPK/ERK pathways.
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Academic Article
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Integration of a Personalized Molecular Targeted Therapy into the Multimodal Treatment of Refractory Childhood Embryonal Tumor with Multilayered Rosettes (ETMR).
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Academic Article
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Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes.
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Academic Article
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Mechanisms of cytokine signal transduction: IL-2, IL-4 and prolactin as hematopoietin receptor models.
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Academic Article
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Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells.
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Academic Article
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Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts.
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Academic Article
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Tyrphostin AG490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts.
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Academic Article
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Tolerance induction by alteration of T cell receptor (TCR) signaling using an allochimeric donor/recipient class I MHC protein.
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Academic Article
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Inhibition of Jak3 tyrosine kinase by PNU156804 blocks rat heart allograft rejection.
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Academic Article
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Selective inhibition of IL-2 mRNA blocks allograft rejection by limiting T cell clonal expansion.
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Academic Article
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Targeting Jak3 for immune suppression and allograft acceptance.
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Academic Article
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PNU156804 inhibits Jak3 tyrosine kinase and rat heart allograft rejection.
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Academic Article
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The role of signals 1, 2, and 3 in induction of transplantation tolerance.
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Academic Article
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The role of Stat5 in the induction of regulatory T cells in transplantation tolerance.
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Academic Article
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Molecular actions of sirolimus: sirolimus and mTor.
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Academic Article
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Specific inhibition of Stat5a/b promotes apoptosis of IL-2-responsive primary and tumor-derived lymphoid cells.
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Academic Article
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Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells.
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Academic Article
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Allochimeric class I MHC protein-induced tolerance by partial TCR engagement requires activation of both CTL4- and common gamma-chain-dependent cytokine signals.
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Academic Article
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New approaches to transplant immunosuppression.
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Academic Article
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Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit.
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Academic Article
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Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells.
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Academic Article
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Janus tyrosine kinases and signal transducers and activators of transcription regulate critical functions of T cells in allograft rejection and transplantation tolerance.
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Academic Article
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JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization.
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Academic Article
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Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.
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Academic Article
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Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.
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Academic Article
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Nitric oxide and thiol redox regulation of Janus kinase activity.
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Concept
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Cyclic AMP
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Concept
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Administration, Oral
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Concept
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Androgens
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Concept
|
Antibodies
|
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Concept
|
Antibodies, Monoclonal
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Concept
|
Antigen-Presenting Cells
|
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Concept
|
Antigens, Differentiation
|
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Concept
|
Antineoplastic Combined Chemotherapy Protocols
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Concept
|
B-Lymphocytes
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|
Concept
|
Bacillus
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Concept
|
Hordeum
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Concept
|
Base Sequence
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Concept
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Benzidines
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Concept
|
Cattle
|
|
Concept
|
Cell Division
|
|
Concept
|
Cloning, Molecular
|
|
Concept
|
Cysteine Endopeptidases
|
|
Concept
|
Electron Transport Complex IV
|
|
Concept
|
Dithiothreitol
|
|
Concept
|
Dose-Response Relationship, Immunologic
|
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Concept
|
Drug Screening Assays, Antitumor
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Concept
|
Drug Therapy, Combination
|
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Concept
|
Electrophoresis, Polyacrylamide Gel
|
|
Concept
|
Enzyme Inhibitors
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|
Concept
|
Enzyme-Linked Immunosorbent Assay
|
|
Concept
|
Leukemia, Erythroblastic, Acute
|
|
Concept
|
Erythropoietin
|
|
Concept
|
Evaluation Studies as Topic
|
|
Concept
|
Flow Cytometry
|
|
Concept
|
Follow-Up Studies
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|
Concept
|
Gastrointestinal Neoplasms
|
|
Concept
|
Gene Expression Regulation
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Concept
|
Genes, Dominant
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Concept
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Graft Rejection
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Concept
|
Graft Survival
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Concept
|
Growth Inhibitors
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Concept
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Health Personnel
|
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Concept
|
T-Lymphocytes, Helper-Inducer
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Concept
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Heme
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Concept
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Hexanes
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Concept
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Histocompatibility Antigens
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Concept
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Hydrogen Peroxide
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Concept
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Immunoglobulin G
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Concept
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Immunoglobulin M
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Concept
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Imidazoles
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Concept
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Immunoglobulin Fab Fragments
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Concept
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Immunoglobulin lambda-Chains
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Concept
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Injections, Intraperitoneal
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Concept
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Interferon-gamma
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Concept
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Interleukin-2
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Concept
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Interleukin-3
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|
Concept
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Interleukins
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Concept
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Iodobenzoates
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Concept
|
Isoelectric Point
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Concept
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Isoproterenol
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Concept
|
Killer Cells, Natural
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Concept
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Kinetics
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Concept
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Leukocytes
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Concept
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Leukocytes, Mononuclear
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Concept
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Lymphocytes
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Concept
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Major Histocompatibility Complex
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Concept
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Mammary Glands, Animal
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Concept
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Mannose
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Concept
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Mice, Inbred BALB C
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Concept
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Mice, Inbred C3H
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Concept
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Milk Proteins
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Concept
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Monocytes
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Concept
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Mutation
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Concept
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Neutrophils
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|
Concept
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Nitric Oxide
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|
Concept
|
Oxidation-Reduction
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|
Concept
|
Peptide Mapping
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|
Concept
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Phagocytosis
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Concept
|
Phosphatidylserines
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|
Concept
|
Phosphoprotein Phosphatases
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|
Concept
|
Phytohemagglutinins
|
|
Concept
|
Plasmids
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Concept
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Polyenes
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Concept
|
Prodigiosin
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Concept
|
Prolactin
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Concept
|
Promoter Regions, Genetic
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|
Concept
|
Protein Processing, Post-Translational
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Concept
|
Pyrazoles
|
|
Concept
|
Pyridazines
|
|
Concept
|
Pyrroles
|
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Concept
|
Genes, ras
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|
Concept
|
Rats, Inbred WF
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|
Concept
|
Receptors, Prolactin
|
|
Concept
|
Recombinant Fusion Proteins
|
|
Concept
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Sheep
|
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Concept
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Spleen
|
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Concept
|
T-Lymphocytes
|
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Concept
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Temperature
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Concept
|
Transcription, Genetic
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Concept
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Transfection
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Concept
|
Protein Biosynthesis
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|
Concept
|
Tumor Stem Cell Assay
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|
Concept
|
Immunoblotting
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|
Concept
|
Blotting, Northern
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Concept
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Blotting, Western
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Concept
|
Electrophoresis, Gel, Two-Dimensional
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|
Concept
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Restriction Mapping
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|
Concept
|
Receptors, Interleukin-2
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|
Concept
|
Histocompatibility Antigens Class I
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Concept
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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Concept
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CD4-Positive T-Lymphocytes
|
|
Concept
|
Transcriptional Activation
|
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Concept
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Down-Regulation
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Concept
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Genomic Library
|
|
Concept
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Antigens, CD
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|
Concept
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Interleukin-4
|
|
Concept
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Interleukin-7
|
|
Concept
|
Up-Regulation
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Concept
|
Gene Expression
|
|
Concept
|
Gene Expression Regulation, Neoplastic
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Concept
|
Survival Rate
|
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Concept
|
Heart Transplantation
|
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Concept
|
Lymphocyte Subsets
|
|
Concept
|
Polymerase Chain Reaction
|
|
Concept
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G1 Phase
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Concept
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Cytokines
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Concept
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Cyclins
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Concept
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Mutagenesis
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Concept
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Mutagenesis, Site-Directed
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Concept
|
Hematopoietic Cell Growth Factors
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Concept
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Lymphoma, T-Cell
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Concept
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Lymphoma, Large B-Cell, Diffuse
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Concept
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Sequence Alignment
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Concept
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Cyclosporine
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Concept
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Culture Media, Serum-Free
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Concept
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Interleukin-9
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Concept
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Gene Deletion
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Concept
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Reactive Oxygen Species
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Concept
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Sequence Deletion
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Concept
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Sequence Analysis, DNA
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Concept
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Prostate-Specific Antigen
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Concept
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Receptors, IgG
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Concept
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Receptors, Erythropoietin
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Concept
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Cyclic AMP-Dependent Protein Kinases
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Concept
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Calcium-Calmodulin-Dependent Protein Kinases
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Concept
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Genes, Reporter
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Concept
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DNA, Complementary
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Concept
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Receptors, Adrenergic, beta-2
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Concept
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Th1 Cells
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Concept
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Th2 Cells
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Concept
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Models, Immunological
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Concept
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Gene Expression Regulation, Developmental
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Concept
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Interleukin-13
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Concept
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Immunoconjugates
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Concept
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Cultural Diversity
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Concept
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Antineoplastic Agents, Alkylating
|
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Concept
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Chemokines
|
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Concept
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Drug Resistance, Neoplasm
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Concept
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Selectins
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Concept
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Jurkat Cells
|
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Concept
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Adoptive Transfer
|
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Concept
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Hematologic Neoplasms
|
|
Concept
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Interleukin-15
|
|
Concept
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COS Cells
|
|
Concept
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Calcineurin
|
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Concept
|
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
|
|
Concept
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Proto-Oncogene Proteins c-raf
|
|
Concept
|
Amino Acid Substitution
|
|
Concept
|
Receptors, Interleukin-4
|
|
Concept
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Mitogen-Activated Protein Kinase 1
|
|
Concept
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Tyrphostins
|
|
Concept
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Sirolimus
|
|
Concept
|
Reverse Transcriptase Polymerase Chain Reaction
|
|
Concept
|
Caspases
|
|
Concept
|
Response Elements
|
|
Concept
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In Situ Nick-End Labeling
|
|
Concept
|
Oligodeoxyribonucleotides, Antisense
|
|
Concept
|
Oligonucleotide Array Sequence Analysis
|
|
Concept
|
GTP Phosphohydrolases
|
|
Concept
|
Son of Sevenless Proteins
|
|
Concept
|
Gene Expression Profiling
|
|
Concept
|
Mitogen-Activated Protein Kinases
|
|
Concept
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Active Transport, Cell Nucleus
|
|
Concept
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Xenograft Model Antitumor Assays
|
|
Concept
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Genomics
|
|
Concept
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Proteomics
|
|
Concept
|
Chromatin Immunoprecipitation
|
|
Concept
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Protein Kinase Inhibitors
|
|
Concept
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JNK Mitogen-Activated Protein Kinases
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|
Concept
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Extracellular Signal-Regulated MAP Kinases
|
|
Concept
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Mitogen-Activated Protein Kinase 3
|
|
Concept
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MAP Kinase Kinase 3
|
|
Concept
|
Proto-Oncogene Proteins A-raf
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|
Concept
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Proto-Oncogene Proteins B-raf
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|
Concept
|
Adaptor Proteins, Signal Transducing
|
|
Concept
|
Cell Proliferation
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|
Concept
|
STAT Transcription Factors
|
|
Concept
|
STAT1 Transcription Factor
|
|
Concept
|
STAT3 Transcription Factor
|
|
Concept
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STAT5 Transcription Factor
|
|
Concept
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STAT6 Transcription Factor
|
|
Concept
|
bcl-X Protein
|
|
Concept
|
Mitochondrial Membranes
|
|
Concept
|
GRB2 Adaptor Protein
|
|
Concept
|
Membrane Potential, Mitochondrial
|
|
Concept
|
Caspase 3
|
|
Concept
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Caspase 8
|
|
Concept
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Caspase 9
|
|
Concept
|
Janus Kinases
|
|
Concept
|
Janus Kinase 1
|
|
Concept
|
Janus Kinase 2
|
|
Concept
|
Janus Kinase 3
|
|
Concept
|
Interleukin Receptor Common gamma Subunit
|
|
Concept
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Interleukin-2 Receptor beta Subunit
|
|
Concept
|
Receptors, Interleukin-9
|
|
Concept
|
DNA Fragmentation
|
|
Concept
|
Precursor Cell Lymphoblastic Leukemia-Lymphoma
|
|
Concept
|
Protein Phosphatase 1
|
|
Concept
|
Protein Phosphatase 2
|
|
Concept
|
Cyclic Nucleotide Phosphodiesterases, Type 4
|
|
Concept
|
Shc Signaling Adaptor Proteins
|
|
Concept
|
Cyclin D
|
|
Concept
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Hep G2 Cells
|
|
Academic Article
|
Direct killing of interleukin-2-transfected tumor cells by human neutrophils.
|
|
Academic Article
|
Pharmacodynamic biomarkers in metronomic chemotherapy: multiplex cytokine measurements in gastrointestinal cancer patients.
|
|
Academic Article
|
The Genomic Landscape of a Restricted ALL Cohort from Patients Residing on the U.S./Mexico Border.
|
|
Academic Article
|
The Many Faces of JAKs and STATs Within the COVID-19 Storm.
|
|
Academic Article
|
Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction.
|
|
Academic Article
|
The SARS-CoV-2 origin dilemma: Zoonotic transfer or laboratory leak?
|
|
Academic Article
|
Quadruple and Truncated MEK3 Mutants Identified from Acute Lymphoblastic Leukemia Promote Degradation and Enhance Proliferation.
|
|
Academic Article
|
Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways.
|
|
Academic Article
|
Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro.
|
|
Academic Article
|
Rapid Shift from SARS-CoV-2 Delta to Omicron Sub-Variants within a Dynamic Southern U.S. Borderplex.
|
|
Academic Article
|
Phosphorylation of Tyrosine 841 Plays a Significant Role in JAK3 Activation.
|
|
Academic Article
|
JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling.
|
|
Academic Article
|
JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation.
|
|
Academic Article
|
Structural Analysis of Janus Tyrosine Kinase Variants in Hematological Malignancies: Implications for Drug Development and Opportunities for Novel Therapeutic Strategies.
|